About Autism - Biomedical Intervention
Autism and Epigenetics
Autistic spectrum disorders arise from a bio-neurological condition-a weakness in a child’s biochemical and neurological development. They seem to go hand in hand and both need to be evaluated for and treated as early as possible. All individuals with autism have these weaknesses in varying degrees.
The basis for the biochemical problems is found in the genes. “More recently, however, researchers began to realize that epigenetics could also help explain certain scientific mysteries that traditional genetics never could; for instance, why one member of a pair of identical twins can develop bipolar disorder or asthma even though the other is fine.Or why autism strikes boys four times as often as girls . . .In these cases, the genes may be the same, but their patterns of expression have clearly been tweaked.
Science is showing that a change in eating patterns can have consequences that reach down the generations. The answer lies in the relatively new field called Epigenetics: the environment’s impact on our genome. There have been changes to our genes as a result of our environment changing and sometimes these changes can cause sickness and diseases. These changes are commonly seen after exposure to certain toxins, including heavy metals, pesticides, and plastics.
What science has found is that there is a layer of programming over the hard gene sequence that basically turns a gene on or off. (Expressed or suppressed) .There are many documented cases of identical twins in which the genes are compared and confirmed identical - yet one is typically developing while the other severely autistic. So in the case of the twins - though they may have the same exact genes that are undamaged, the programming that turns the autistic child's genes on and off is off kilter. Altered function in your DNA will cause an alteration in your biochemistry, which leads to altered human function. This is the case of autism.
 What Can Be Done to Prevent Autism Now?: by Maureen H. McDonnell, R.N.

 It’s a fact that more and more kids are showing signs of autism spectrum disorders (ASD) than ever before.

 What’s  causing this epidemic is still a mystery, but we now have some strong clues about prevention and

 treatment, based on emerging science and parents reporting the specific treatments that have created

 improvement (and, in some cases, recovery) in their children.

Autism: Traditional / A Bio Medical View Point 
 The traditional view is that autism is a group of behaviors caused by some defective gene or genes     that  enacted structural changes in the brain before the child was born. Traditional thinking dictates that because doctor’s can’t repair structural brain abnormalities, they can do nothing to improve the child’s level of functioning other than providing behavioral therapies.
As per the biomedical approach, autism is based on different idea- that autistic children have metabolic problems that doctors can diagnose and treat. Fixing broken biochemical pathways improves the immune system, and helps to heal the gut, making the child feel better physically. Biomedical thinking insists that by paying attention to the medical issues of the children, alongwith the psychiatric and educational facets, caregivers and physicians can significantly improves the
“By implementing the DAN Biomedical approach these children can be greatly helped medically, behaviourally ,and cognitively by proper diagnosis and treatment of their underlying medical conditions” By Jaquelyn MacCandless, M.D.
      A BioMedical Approach: Theory
 Novel and emerging treatments for autism spectrum disorders: A systematic review: Daniel A. Rossignol, MD, FAAFP
International Child Development Resource Center, Melbourne, FL, USA
BACKGROUND: Currently, only one medication (risperidone) is FDA-approved for the treatment of autism spectrum disorders (ASD). Perhaps for this reason, the use of novel, unconventional, and off-label treatments for ASD is common, with up to 74% of children with ASD using these treatments; however, treating physicians are often unaware of this usage.
METHODS: A systematic literature search of electronic scientific databases was performed to identify studies of novel and emerging treatments for ASD, including nutritional supplements, diets, medications, and nonbiological treatments. A grade of recommendation (“Grade”) was then assigned to each treatment using a validated evidence-based guideline as outlined in this review:
A: Supported by at least 2 prospective randomized controlled trials (RCTs) or 1 systematic review
B: Supported by at least 1 prospective RCT or 2 nonrandomized controlled trials
C: Supported by at least 1 nonrandomized controlled trial or 2 case series
D: Troublingly inconsistent or inconclusive studies or studies reporting no improvements
Potential adverse effects for each treatment were also reviewed.
RESULTS: Grade A treatments for ASD include melatonin, acetylcholinesterase inhibitors, naltrexone, and music therapy. Grade B treatments include carnitine, tetrahydrobiopterin, vitamin C, alpha-2 adrenergic agonists, hyperbaric oxygen treatment, immunomodulation and anti-inflammatory treatments, oxytocin, and vision therapy. Grade C treatments for ASD include carnosine, multivitamin/mineral complex, piracetam, polyunsaturated fatty acids, vitamin B6/magnesium, elimination diets, chelation, cyproheptadine, famotidine, glutamate antagonists, acupuncture, auditory integration training, massage, and neurofeedback.
CONCLUSIONS: The reviewed treatments for ASD are commonly used, and some are supported by prospective RCTs. Promising treatments include melatonin, antioxidants, acetylcholinesterase inhibitors, naltrexone, and music therapy. All of the reviewed treatments are currently considered off-label for ASD (ie, not FDA-approved) and some have adverse effects. Further studies exploring these treatments are needed. Physicians treating children with an ASD should make it standard practice to inquire about each child’s possible use of these types of treatments.
A BioMedical Approach : Treatment


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