Methyl B12 shots First Treatment provided by AAF in India


“Role of M-B12 Injections in children with Autism Spectrum Disorders (ASD)”

Dr Deepak Gupta, a child psychiatrist practising at New Delhi associated with Sir Ganga Ram Hospital and has his own multidisciplinary set up and EIS centre (CCAW) at Greater Kailash, New Delhi.
Got  trained at DAN conference at DALLAS, Texas oct 2009 supported by Akhil Autism Foundation (New Jersey) . Also with the support of Akhil Autism Foundation (New Jersey) has  been treating children with Biomedical Protocol incluidng MB12 shots. On 24th Nov 2009 he presented a poster at AIIMS at the National Conference showing the efficay of MB12 shots in children with ASD and how the ATEC scores have improved over the few months.

The biomedical approaches incuding MB12 shots seems to be a proming intervention for our children with ASD.









B12 Injections in children with Autism Spectrum Disorders (ASD)”


Methylation is a critical process for DNA synthesis and repair, protection of DNA and RNA against insertion of viral genes, neuronal myelination and pruning, glutathione production, homocysteine regulation, control of gene expression, metabolic detoxification, and formation of neurotransmitters melatonin, serotonin, creatine, and phospholipids.

A key area in the study of autism involves environmental toxicity and deficient detoxification, with one of the main biochemical pathways of interest being the methylation cycle (Figure 1).


The Methylation Cycle




 This pathway regenerates methionine from homocysteine, via vitamin B12-dependent methionine synthase.

Many autistic kids have low serum methioine, SAM and homocysteine levels pointing to reduced activity of methionine synthase and the decreased turnover of the methionine cycle methylcobalamin (75mcg/kg) two times per week given subcutaneously for one month, the study found levels of plasma methionine increased


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